Vitamin E and oxidative stress in abetalipoproteinemia and familial hypobetalipoproteinemia
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- 作者：John R. Burnetta ; b ; john.burnett@health.wa.gov.au" class="auth_mail" title="E-mail the corresponding author ; Amanda J. Hoopera ; b ; c
- 关键词：ABL ; abetalipoproteinemia ; apoB ; apolipoprotein B ; FHBL ; familial hypobetalipoproteinemia ; HDL ; high density lipoprotein ; HBL ; hypobetalipoproteinemia ; LDL ; low density lipoprotein ; MTP ; microsomal triglyceride transfer protein ; PDI ; protein disulfide isomerase ; VLDL ; very low density lipoprotein
- 刊名：Free Radical Biology and Medicine
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：88
- 期：part_PA
- 页码：59-62
- 全文大小：276 K
文摘
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Vitamin E and A deficiency is a feature of abetalipoproteinemia (ABL).
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High-dose vitamin E and A supplementation prevents or halts neuropathy and retinopathy in ABL.
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There are conflicting reports on whether increased oxidative stress is seen in ABL.
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These differences may relate to patient age and vitamin E dose.
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Oxidized HDL from patients with ABL inhibits platelet aggregation.