Interdependence between Interleukin-1 and Tumor Necrosis Factor Regulates TNF-Dependent Control of Mycobacterium tuberculosis Infection
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- 作者：Nelson C. Di Paolo1 ; 8 ; ncdipaolo@emory.edu" class="auth_mail" title="E-mail the corresponding author ; Shahin Shafiani2 ; 8 ; Tracey Day2 ; 9 ; Thalia Papayannopoulou3 ; David W. Russell3 ; Yoichiro Iwakura4 ; David Sherman2 ; Kevin Urdahl2 ; 5 ; Dmitry M. Shayakhmetov1 ; 6 ; 7 ; dmitryshay@emory.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2015
- 出版时间：15 December 2015
- 年：2015
- 卷：43
- 期：6
- 页码：1125-1136
- 全文大小：5190 K
文摘
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TNF-α fails to control Mtb replication in the absence of functional IL-1RI
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IL-1 and TNF signaling pathways cooperate to establish optimal Mtb control
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IL-1α is critical for protective granuloma formation
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IL-1α plays a non-redundant role in mounting host resistance to Mtb