Caffeine exposure during rat brain development causes memory impairment in a sex selective manner that is offset by caffeine consumption throughout life
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- 作者：Ana Paula Ardaisa ; André ; ia S. Rochaa ; Maurí ; cio Felisberto Borgesa ; Gabriela T. Fiorezea ; Cá ; ssia Sallaberrya ; Sabrina Mioranzzaa ; Fernanda Nunesa ; Natá ; lia Pagnussata ; Paulo Henrique S. Bottona ; Rodrigo A. Cunhab ; c ; Lisiane de Oliveira Porciú ; nculaa ; loporciuncula@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：BDNF ; brain-derived neurotrophic factor ; TrkB ; tropomyosin receptor kinase B ; GFAP ; glial fibrillar acid protein ; SNAP-25 ; synaptosomal-associated protein 25
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：303
- 期：Complete
- 页码：76-84
- 全文大小：2284 K
文摘
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Behavior and synaptic proteins were modified by caffeine throughout life and during development.
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Adult female rats receiving caffeine during development displayed impaired recognition memory.
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Caffeine at highest dose throughout life attenuates anxiety-related behavior in both sexes.
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Caffeine treatments modified locomotion in a different manner according to sexes.
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Caffeine treatments change BDNF and related proteins in the hippocampus from both sexes.