文摘
Cognition-enhancing effects of SP-NN, a silk peptide preparation, were investigated. SP-NN enhanced ChAT mRNA expression in F3.ChAT neural stem cells and Neuro-2a neuroblastoma cells. Active molecule was identified as a dipeptide composed of tyrosine-glycine. SP-NN reversed cognitive dysfunction elicited by AF64A. Neuroprotection followed by increased acetylcholine level was achieved with SP-NN.