Local fibroblast proliferation but not influx is responsible for synovial hyperplasia in a murine model of rheumatoid arthritis
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- 作者：Yusuke Matsuoa ; b ; Fumitaka Mizoguchia ; b ; Tetsuya Saitoa ; b ; Kimito Kawahataa ; Satoshi Uehab ; c ; Kouji Matsushimab ; c ; Yutaka Inagakib ; d ; Nobuyuki Miyasakaa ; Hitoshi Kohsakaa ; b ; kohsaka.rheu@tmd.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Rheumatoid arthritis ; Collagen antibody-induced arthritis ; Synovial fibroblast ; Synovial hyperplasia ; Cellular proliferation ; Cellular influx
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：12 February 2016
- 年：2016
- 卷：470
- 期：3
- 页码：504-509
- 全文大小：1573 K
文摘
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We studied how synovial fibroblasts accumulate in joints in a murine model of RA.
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Bone marrow-derived cells did not accumulate in arthritic joints.
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Synovial fibroblasts did not accumulate in arthritic joints via circulation.
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Local proliferation was responsible for the synovial fibroblast accumulation.