Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in rats

详细信息    查看全文

• 作者：Joana Sagradas^a ; Gustavo Costa^b ; Artur Figueirinha^c ; Maria Margarida Castel-Branco^a ; ^d ; Antó ; nio Manuel Silvé ; rio Cabrita^e ; Isabel Vitó ; ria Figueiredo^a ; ^d ; Maria Teresa Batista^b ; ^{mtpmb@ff.uc.pt" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Cymbopogon citratus ; Lemongrass ; Infusion ; Gastric ulcer ; Gastroprotective
• 刊名：Journal of Ethnopharmacology
• 出版年：2015
• 出版时间：15 September 2015
• 年：2015
• 卷：173
• 期：Complete
• 页码：134-138
• 全文大小：836 K

文摘

Treatment of gastric ulcers with medicinal plants is quite common in traditional medicine worldwide. Cymbopogon citratus (DC) Stapf. leaves infusion has been used in folk medicine of many tropical and subtropical regions to treat gastric disturbances. The aim of this study was to assess the potential gastroprotective activity of an essential oil-free infusion from C. citratus leaves in acute gastric lesions induced by ethanol in rat.

Materials and methods

The study was performed on adult male Wistar rats (234.0±22.7 g) fasted for 24 h but with free access to water. The extract was given orally before (prevention) or after (treatment) intragastric administration of absolute ethanol. Effects of dose (28 or 56 mg/kg of body weight) and time of contact of the extract with gastric mucosa (1 or 2 h) were also assessed. Animals were sacrificed, being the stomachs removed and the lesions were assessed by macroscopic observation and histopathology.

Results

C. citratus extract, given orally before or after ethanol, significantly (P<0.01) reduced gastric mucosal injury compared with control group (vehicle+ethanol). The effect does not appear to be dose-dependent. Results also suggested that the extract is more effective when the time of contact with gastric mucosa increases.

Conclusions

The results of this assay confirm the gastroprotective activity of C. citratus extract on experimental gastric lesions induced by ethanol, contributing for the pharmacological validation of its traditional use.