Prevention of radiation-induced bone pathology through combined pharmacologic cytoprotection and angiogenic stimulation
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- 作者：Alexis Donneys ; Noah S. Nelson ; Joseph E. Perosky ; Yekaterina Polyatskaya ; Jose J. Rodriguez ; Christian Figueredo ; Cheyenne A. Vasseli ; Hannah C. Ratliff ; Sagar S. Deshpande ; Kenneth M. Kozloff ; Steven R. Buchman ; sbuchman@med.umich.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Radiotherapy ; Osteoradionecrosis ; Pathologic fracture ; Nonunion ; Deferoxamine ; Amifostine
- 刊名：Bone
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：84
- 期：Complete
- 页码：245-252
- 全文大小：1207 K
文摘
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We examine a combination treatment for radiation-induced changes to bone healing.
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Angiographic modeling, histology and biomechanics quantified bone healing.
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Investigation of combined amifostine plus deferoxamine treatment is reported.