A mollusk VDR/PXR/CAR-like (NR1J) nuclear receptor provides insight into ancient detoxification mechanisms

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• 作者：Catarina Cruzeiro^a ; ^b ; ^{catarinarcruzeiro@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Mó ; nica Lopes-Marques^a ; ^b ; ^{monicaslm@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Raquel Ruivo^b ; ^{ruivo.raquel@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ná ; dia Rodrigues-Oliveira^b ; ^{nadia.oliveira@ciimar.up.pt" class="auth_mail" title="E-mail the corresponding author} ; Miguel M. Santos^b ; ^c ; ^{santos@ciimar.up.pt" class="auth_mail" title="E-mail the corresponding author} ; Maria Jo&atilde ; o Rocha^a ; ^b ; ^{mjsrocha@netcabo.pt" class="auth_mail" title="E-mail the corresponding author} ; Eduardo Rocha^a ; ^b ; ^{erocha@icbas.up.pt" class="auth_mail" title="E-mail the corresponding author} ; L. Filipe C. Castro^b ; ^c ; ^{filipe.castro@ciimar.up.pt" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Nuclear receptors ; VDR/PXR/CAR ; Pesticides ; Okadaic acid ; Molluscs
• 刊名：Aquatic Toxicology
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：174
• 期：Complete
• 页码：61-69
• 全文大小：1642 K

文摘

<dl class="listitem" id="list_lis0005"><dt class="label">•dt><dd>

d="par0005">A nuclear receptor orthologue of the NR1J group is isolated from a mollusc.

dd><dt class="label">•dt><dd>

d="par0010">The molluscan NR1J transactivates gene expression upon exposure to okadaic acid but not a pesticide, esfenvarelate and triclosan.

dd><dt class="label">•dt><dd>

d="par0015">Lineage specific gene duplications and gene loss have occurred in the NR1J of protostomes with likely impacts on detoxification mechanisms.

dd>dl>