Adaptive Immunity Dysregulation in Acute Coronary Syndromes: From Cellular and Molecular Basis to Clinical Implications

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• 作者：Davide Flego ; PhD^a ; Giovanna Liuzzo ; MD ; PhD^a ; ^{giovanna.liuzzo@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Cornelia M. Weyand ; MD ; PhD^b ; Filippo Crea ; MD^a
• 关键词：outcome ; pathogenesis ; signaling ; treatment
• 刊名：Journal of the American College of Cardiology
• 出版年：2016
• 出版时间：8 November 2016
• 年：2016
• 卷：68
• 期：19
• 页码：2107-2117
• 全文大小：1501 K

文摘

Although the early outcome of acute coronary syndrome (ACS) has considerably improved in the last decade, cardiovascular diseases still represent the main cause of morbidity and mortality worldwide. This is mainly because recurrence of ACS eventually leads to the pandemics of heart failure and sudden cardiac death, thus calling for a reappraisal of the mechanisms responsible for coronary instability. This review discusses recent advances in our understanding of how adaptive immunity contributes to the pathogenesis of ACS and the clinical implications that arise from these new pathogenic concepts.