The Lupus Autoantigen La Prevents Mis-channeling of tRNA Fragments into the Human MicroRNA Pathway
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- 作者：Daniele Hasler1 ; Gerhard Lehmann1 ; Yasuhiro Murakawa2 ; 5 ; Filippos Klironomos3 ; Leonhard Jakob1 ; Friedrich A. Grä ; sser4 ; Nikolaus Rajewsky3 ; Markus Landthaler2 ; Gunter Meister1 ; gunter.meister@vkl.uni-regensburg.de" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：7 July 2016
- 年：2016
- 卷：63
- 期：1
- 页码：110-124
- 全文大小：4049 K
文摘
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La prevents processing of specific pre-tRNAs by the miRNA-biogenesis machinery
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The chimeric RNA pre-tRNA-Ile-2-3 generates a functional tRNA and miR-1983
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Pre-tRNA-Ile-2-3 escapes La regulation by distinct folding strategies
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Viral ncRNAs perturb La’s gatekeeper function and induce sRNA production from tRNAs