Unambiguous Identification of miRNA:Target Site Interactions by Different Types of Ligation Reactions
详细信息 查看全文
- 作者：Stefanie Grosswendt1 ; 3 ; Andrei Filipchyk1 ; 3 ; Mark Manzano2 ; Filippos Klironomos1 ; Marcel Schilling1 ; Margareta Herzog1 ; Eva Gottwein2 ; Nikolaus Rajewsky1 ; rajewsky@mdc-berlin.de" class="auth_mail
- 刊名：Molecular Cell
- 出版年：19 June 2014
- 年：2014
- 卷：54
- 期：6
- 页码：1042-1054
- 全文大小：1520 K
文摘
- •
Comprehensive AGO binding map and thousands of miRNA:target interactions in C. elegans
- •
AGO-CLIP samples contain miRNA:target chimeras generated by an endogenous ligase
- •
From human and other systems, 17,000 miRNA interactions are largely functional
- •
Seed sites are present in 80% of interactions; roughly half of them are imperfect