We tested the idea that peroxynitrite (ONOO−) may affect fibrinolysis in human blood.
ONOO− enhanced lysis of platelet-fibrin but not platelet-depleted clots.
ONOO− inhibited platelet secretion, clot retraction and procoagulant response.
These effects contribute to altered clot structure toward more prone to lysis.
ONOO−, in vitro, reduces platelet-dependent fibrinolysis resistance.