Plasminogen activator inhibitor type 1 in platelets induces thrombogenicity by increasing thrombolysis resistance under shear stress in an in-vitro flow chamber model
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- 作者：Kazuya Hosokawaa ; Tomoko Ohnishi-Wadaa ; Hisayo Sameshima-Kanekoa ; Tomoka Nagasatoa ; b ; Naoki Miurac ; Kiyoshi Kikuchid ; e ; Takehiko Koideb ; Ikuro Maruyamab ; Tetsumei Uranof ; uranot@hama-med.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：AUC30 ; area under the flow pressure curve ; CFT ; clot formation time ; CT ; clotting time ; CTI ; corn trypsin inhibitor ; MCF ; maximum clot firmness ; ML ; maximum lysis ; OT ; occlusion time ; PAI-1 ; plasminogen activator inhibitor type 1 ; ROTEM ; rotational thromboelastometry ; T10 ; time to 10 ; kPa ; TEG ; thromboelastography ; TF ; tissue factor ; t-PA ; tissue plasminogen activator ; u-PA ; urokinase type PA ; WT ; wild-type
- 刊名：Thrombosis Research
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：146
- 期：Complete
- 页码：69-75
- 全文大小：1184 K
文摘
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Shear rate largely modified thrombolytic efficacy of t-PA.
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PAI-1 inhibitor enhanced the thrombolytic efficacy of t-PA under arterial shear rate.
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PAI-1 secreted from platelets appeared to potently regulate arterial thrombolysis.