The JAK/STAT Pathway Is Involved in Synaptic Plasticity

详细信息    查看全文

• 作者：Cé ; line  ; S. Nicolas¹ ; ⁸ ; Sté ; phane Peineau¹ ; ² ; ³ ; ⁸ ; Mascia Amici¹ ; Zsolt Csaba² ; ³ ; Assia Fafouri² ; ³ ; Charlotte Javalet¹ ; Valerie  ; J. Collett¹ ; Lars Hildebrandt⁴ ; Gillian Seaton⁴ ; Sun-Lim Choi⁵ ; ⁶ ; Su-Eon Sim⁵ ; Clarrisa Bradley⁵ ; Kyungmin Lee⁷ ; Min Zhuo⁵ ; Bong-Kiun Kaang⁵ ; ⁶ ; Pierre Gressens² ; ³ ; Pascal Dournaud² ; ³ ; Stephen  ; M. Fitzjohn¹ ; ⁹ ; Zuner  ; A. Bortolotto¹ ; Kwangwook Cho⁴ ; Graham  ; L. Collingridge¹ ; ⁴ ; ⁵ ; ^{g.l.collingridge@bristol.ac.uk}
• 刊名：Neuron
• 出版年：2012
• 出版时间：26 January 2012
• 年：2012
• 卷：73
• 期：2
• 页码：374-390
• 全文大小：2276 K

文摘

| Figures/TablesFigures/Tables | ReferencesReferencesml version=""1.0"" encoding=""UTF-8""?>

Summary

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD). Here, we demonstrate a new neuronal function for the JAK/STAT pathway. Using a variety of complementary approaches, we show that the JAK/STAT pathway plays an essential role in the induction of NMDA-receptor dependent long-term depression (NMDAR-LTD) in the hippocampus. Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain.