Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner
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- 作者：Susan F. Fitzpatricka ; 1 ; Zsolt Fá ; biá ; na ; 1 ; Bettina Schaiblea ; 1 ; Colin R. Lenihana ; 1 ; Thomas Schwarzla ; Javier Rodriguezc ; Xingnan Zhengd ; Zongwei Lid ; Murtaza M. Tambuwalae ; Desmond G. Higginsa ; Yvonne O'Mearaa ; Craig Slatteryb ; Mario C. Manresaa ; Peter Fraislf ; Ulrike Bruningf ; Myriam Baesg ; Peter Carmelietf ; Glen Dohertyf ; Alex von Kriegsheimc ; Eoin P. Cumminsa ; Cormac T. Taylora ; cormac.taylor@ucd.ie" class="auth_mail" title="E-mail the corresponding author
- 关键词：Prolyl hydroxylase ; NF-κB ; Apoptosis ; Hypoxia
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：3 June 2016
- 年：2016
- 卷：474
- 期：3
- 页码：579-586
- 全文大小：2047 K
文摘
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Genetic ablation of PHD1 upregulates NF-kappaB (NF-κB) in hepatocytes.
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Activation of NF-κB leads to differential DNA-binding of p50/p65 and results in differential regulation of apoptotic genes.
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We identified proline 191 in the beta subunit of the I-kappaB kinase as a target for PHD1-mediated hydroxylation.
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Blockade of prolyl-4-hydroxylases has been found cytoprotective in liver cells.