Kunitzins: Prototypes of a new class of protease inhibitor from the skin secretions of European and Asian frogs
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- 作者：Xiaole Chena ; leochen5139@fjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; He Wangb ; hwang11@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Yue Shenc ; Lei Wangc ; Mei Zhouc ; Tianbao Chenc ; Chris Shawc
- 关键词：Amphibian ; Protease inhibitor ; Peptide ; Cloning ; Antimicrobial ; Cleavage
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：19 August 2016
- 年：2016
- 卷：477
- 期：2
- 页码：302-309
- 全文大小：1789 K
文摘
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Novel kunitzins, a new class of protease inhibitor, were identified from the skin secretions of European and Asian frogs.
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Novel isolated kunitzins display a narrow-spectrum antibacterial activity and potent inhibitory activity against trypsin.
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Single-site substitutions in the P1 site of the conserved Kuniz-type motif can change the bioactivities of kunitzins.