Expression of Endoplasmic Reticulum-Mediated Stress Proteins in FK506-Treated T-Lymphocytes
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- 作者：H.K. Leea ; M.W. Chungb ; Y.W. Chunga ; S.K. Choib ; S.J.N. Choia ; S.Y. Chunga ; sycpvts@chonnam.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 刊名：Transplantation Proceedings
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：48
- 期：4
- 页码：1292-1296
- 全文大小：746 K
文摘
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Apoptotic signals are delivered to caspase-3, -9, or both in different cells via the death receptor (Fas/FasL), mitochondria (Bax/Bcl-2) or by the ER through initiators of caspase-8, -9, or -12. FK506-induced apoptosis was characterized by nuclear fragmentation and caspase 3 activation.
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Expression of Grp78 and Grp94/BiP, PERK, and CHOP proteins was also identified.
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The CHOP protein is a key protein in the ER stress protein–mediated apoptotic pathway. FK506 dose-dependently decreases Jurkat cell viability by activating apoptosis signaling and inducing ER stress proteins.