Crystal Structure of a Multi-domain Immunophilin from Arabidopsis thaliana: A Paradigm for Regulation of Plant ABC Transporters

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• 作者：Joachim Granzin ; Andreas Eckhoff ; Oliver H. Weiergrä ; ber
• 关键词：FKBP42 ; Arabidopsis thaliana ; X-ray crystallography ; HSP90 ; ABC transporter
• 刊名：Journal of Molecular Biology
• 出版年：2006
• 出版时间：8 December 2006
• 年：2006
• 卷：364
• 期：4
• 页码：799-809
• 全文大小：1418 K

文摘

FKBP42 is a membrane-anchored immunophilin playing a critical role in morphogenesis and development of higher plants. We present the X-ray structure of the cytoplasmic portion of FKBP42 comprising both the FKBP-like domain and the TPR domain at 2.85 Å resolution. The data shed light on the probable binding modes of key interaction partners, including HSP90 and two classes of ABC transporters. The resulting models provide a structural background for further investigation of the unique biological properties of this protein.