ID4 promotes AR expression and blocks tumorigenicity of PC3 prostate cancer cells
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- 作者：Shravan Kumar Komaragiri ; Dhanushka H. Bostanthirige ; Derrick J. Morton ; Divya Patel ; Jugal Joshi ; Sunil Upadhyay ; Jaideep Chaudhary ; jchaudhary@cau.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ID4 ; AR ; ADT ; p21 ; FKBP51 ; bHLH ; Cancer ; Apoptosis ; Migration
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：9 September 2016
- 年：2016
- 卷：478
- 期：1
- 页码：60-66
- 全文大小：1215 K
文摘
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ID4 expression induces AR expression in PC3 cells, which generally lack AR.
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ID4 expression increased apoptosis and decreased cell proliferation and invasion.
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Overexpression of ID4 reduces tumor growth of subcutaneous xenografts in vivo.
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ID4 induces p21 and FKBP51 expression- co-factors of AR tumor suppressor activity.