Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus

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• 作者：Keiko Rausch¹ ; ⁷ ; Brent A. Hackett¹ ; ⁷ ; Nathan L. Weinbren¹ ; Sophia M. Reeder¹ ; Yoel Sadovsky⁴ ; ⁵ ; ⁶ ; Christopher A. Hunter² ; David C. Schultz³ ; Carolyn B. Coyne⁴ ; ⁵ ; ⁶ ; Sara Cherry¹ ; ⁸ ; ^{cherrys@mail.med.upenn.edu}
• 关键词：antivirals ; flavivirus ; arbovirus ; therapeutics ; repurposing ; drugs ; entry
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：17 January 2017
• 年：2017
• 卷：18
• 期：3
• 页码：804-815
• 全文大小：4653 K
• 卷排序：18

文摘

2,000 compounds were screened in three cell types against Zika virus 38 compounds had antiviral activity in at least one cell type Nanchangmycin had antiviral activity in all cell types tested Nanchangmycin was active against diverse arboviruses