Aminopurine and aminoquinazoline scaffolds for development of potential dengue virus inhibitors

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• 作者：Akkaladevi Venkatesham^a ; Milind Saudi^a ; Suzanne Kaptein^b ; Johan Neyts^b ; Jef Rozenski^a ; Mathy Froeyen^a ; Arthur Van Aerschot^a ; ^{Arthur.Vanaerschot@rega.kuleuven.be}
• 关键词：Flavivirus inhibitors ; Dengue virus ; Diaminopurines ; Diaminoquinazolines ; NS5 polymerase
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：27 January 2017
• 年：2017
• 卷：126
• 期：Complete
• 页码：101-109
• 全文大小：1159 K
• 卷排序：126

文摘

Some bis-aminated purine and quinazoline derivatives are envisaged as antivirals. Different synthetic strategies have been discussed. Activities at micromolar levels were noted for inhibition of dengue virus. Molecular docking confirms the NS5 polymerase to be the probable target. Bis-aminated purine and quinazoline scaffolds deserve further study as antivirals.