Seladoeflavones A-F, six novel flavonoids from Selaginella doederleinii

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• 作者：ZhenXing Zou^a ; ^b ; KangPing Xu^b ; PingSheng Xu^a ; XiaoMin Li^a ; Fei Cheng^b ; Jing Li^b ; Xia Yu^b ; DongSheng Cao^b ; Dan Li^a ; Wei Zeng^a ; GuoGang Zhang^a ; ^{xyzgg2006@sina.com} ; GuiShan Tan^a ; ^b ; ^{tgs395@csu.edu.cn}
• 关键词：Selaginella ; Selaginella doederleinii ; Unique flavonoids ; Cytotoxicity
• 刊名：Fitoterapia
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：116
• 期：Complete
• 页码：66-71
• 全文大小：569 K
• 卷排序：116

文摘

Six new flavonoids, seladoeflavones A–F (1–6), were isolated from the whole herbs of Selaginella doederleinii, together with one known flavonoid (7). Their structures including absolute configuration were characterized on the basis of extensive spectroscopic methods including NMR, HRMS, and electronic circular dichroism (ECD). All compounds consist of an aryl substituent at the C-3′ position of naringenin or apigenin skeletons, and compounds 1 and 6 were identified as R configurations, which are uncommonly encountered in nature. A possible biosynthetic pathway was postulated. In addition, bioassay of the isolates revealed that 5–7 exhibited moderate cytotoxicity against three human cancer cell lines NCI-H460, A549, and K562 in vitro with IC50 values ranging from 8.17 to 18.66 μM.