Arterial Myogenic Activation through Smooth Muscle Filamin A
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- 作者：Kevin Retailleau1 ; Malika Arhatte1 ; Sophie Demolombe1 ; Ré ; mi Peyronnet1 ; Vé ; ronique Baudrie2 ; Martine Jodar1 ; Jennifer Bourreau3 ; Daniel Henrion3 ; Stefan Offermanns4 ; Fumihiko Nakamura5 ; Yuanyi Feng6 ; Amanda Patel1 ; Fabrice Duprat1 ; 7 ; Eric Honoré ; 1 ; 7 ; honore@ipmc.cnrs.fr" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：8 March 2016
- 年：2016
- 卷：14
- 期：9
- 页码：2050-2058
- 全文大小：1992 K
文摘
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Deletion of smFlnA at the adult stage has a hypotensive effect
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smFlnA is critically required for the arterial myogenic tone
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Loss of smFlnA impairs pressure-dependent calcium influx
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Stretch activates the voltage-gated CaV1.2 channel in a FlnA-dependent manner