刊名:Biochimica et Biophysica Acta (BBA) - Bioenergetics
出版年:2017
出版时间:February 2017
年:2017
卷:1858
期:2
页码:175-181
全文大小:798 K
卷排序:1858
文摘
We deleted the gene for NUYM (NDUFS4) of mitochondrial complex I in Yarrowia lipolytica. We observed distortion of two iron-sulfur clusters and increased ROS formation. Assembly factor N7BML (NDUFAF2) remained bound to complex I. The data shed new light on pathogenic NDUFS4 mutations in humans.