Pulmonary anti-inflammatory effects and spasmolytic properties of Costa Rican noni juice (Morinda citrifolia L.)

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• 作者：Emilie Dussossoy^a ; ¹ ; ^{emilie.dussossoy@etu.umontpellier.fr" class="auth_mail" title="E-mail the corresponding author} ; Florence Bichon^a ; ² ; ^{florence.bichon@umontpellier.fr" class="auth_mail" title="E-mail the corresponding author} ; Emilie Bony^a ; ² ; ^{emilie.bony@etu.umontpellier.fr" class="auth_mail" title="E-mail the corresponding author} ; Karine Portet^a ; ² ; ^{karine.portet@umontpellier.fr" class="auth_mail" title="E-mail the corresponding author} ; Pierre Brat^b ; ³ ; ^{pierre.brat@cirad.fr" class="auth_mail" title="E-mail the corresponding author} ; Fabrice Vaillant^b ; ³ ; ^{fabrice.vaillant@cirad.fr" class="auth_mail" title="E-mail the corresponding author} ; Alain Michel^a ; ⁴ ; ^{alain.michel@univ-montp1.fr" class="auth_mail" title="E-mail the corresponding author} ; Patrick Poucheret^a ; ⁵ ; ^{patrick.poucheret@umontpellier.fr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Noni ; Morinda citrifolia L. ; Anti-inflammatory activity ; Spasmolytic activity
• 刊名：Journal of Ethnopharmacology
• 出版年：2016
• 出版时间：4 November 2016
• 年：2016
• 卷：192
• 期：Complete
• 页码：264-272
• 全文大小：513 K

文摘

Morinda citrifolia L. (Noni) is a medicinal plant used in Polynesia for many properties such as anti-inflammatory, anti-diabetic and antineoplastic effects. Recent studies showed that noni juice have anti-oxidant and acute anti-inflammatory activities likely due to polyphenols, iridoids and vitamin C content. The present study was undertaken to evaluate chronic anti-inflammatory and spasmolytic effects of noni juice.

Materials and methods

Therefore, we evaluated the effect of oral or intraperitoneal administrations of noni juice in vivo on the lung inflammation in ovalbumin (OVA) sensitized Brown Norway rat (with prednisolone 10 mg/kg intraperitoneously as reference compound) and the ex vivo effect of noni juice on BaCl₂ (calcium signal) or methacholine (cholinergic signal) induced spasms in jejunum segments.

Results

We found that noni juice (intraperitoneously 2.17 mL/kg and orally 4.55 mL/kg) reduced the inflammation in OVA-sensitized Brown Norway rat with regard to the decreased number of inflammatory cells in lung (macrophages minus 20–26%, lymphocytes minus 58–34%, eosinophils minus 53–30%, neutrophils minus 70–28% respectively). Noni juice demonstrated a dose-dependent NO scavenging effect up to 8.1 nmol of nitrites for 50 µL of noni juice. In addition noni juice inhibited (up to 90%) calcium and cholinergic induced spasms on the jejunum segments model with a rightward shift of the concentration response curve.

Conclusion

We describe for the first time that noni juice demonstrate (1) a chronic anti-inflammatory activity on sensitized lungs along with (2) a spasmolytic effect integrating a calcium channel blocker activity component.