Synthetic UDP-furanoses inhibit the growth of the parasite Leishmania

详细信息    查看全文

• 作者：Ré ; my Dureau ; Florence Robert-Gangneux ; Jean-Pierre Gangneux ; Caroline Nugier-Chauvin ; Laurent Legentil ; Richard Daniellou ; Vincent Ferriè ; res
• 关键词：UDP-furanoses ; Leishmania ; Hexofuranosides ; Visceral leishmaniasis
• 刊名：Carbohydrate Research
• 出版年：2010
• 出版时间：2 July 2010
• 年：2010
• 卷：345
• 期：10
• 页码：1299-1305
• 全文大小：619 K

文摘

The chemical synthesis of UDP-6-NHAc-6-deoxy-Galf was performed and it led to the isolation of both pure anomers. They were then evaluated together with the previously prepared UDP-furanoses for their anti-parasitic properties against Leishmania donovani promastigotes, one of the agents responsible for visceral leishmaniasis. Amongst them, the unnatural 1,2-trans UDP-6-NHAc-Galf demonstrated a high potency in inhibiting the growth of the parasite.