Local tumor control probability modeling of primary and secondary lung tumors in stereotactic body radiotherapy

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• 作者：Matthias Guckenberger^a ; ^b ; ; Rainer J. Klement^c ; Michael Allg&auml ; uer^d ; Nicolaus Andratschke^b ; ^e ; Oliver Blanck^f ; Judit Boda-Heggemann^g ; Karin Dieckmann^h ; Marciana Dumaⁱ ; Iris Ernst^j ; Ute Ganswindt^k ; Peter Hass^l ; Christoph Henkenberens^m ; Richard Holyⁿ ; Detlef Imhoff^o ; Henning K. Kahl^p ; Robert Krempien^q ; Fabian Lohaus^r ; Ursula Nestle^s ; Meinhard Nevinny-Stickel^t ; Cordula Petersen^u ; Sabine Semrau^v ; Jan Streblow^w ; Thomas G. Wendt^x ; Andrea Wittig^y ; Michael Flentje^a ; Florian Sterzing^w
• 关键词：Stereotactic body radiotherapy ; Lung metastases ; Non-small cell lung cancer ; Tumor control probability
• 刊名：Radiotherapy and Oncology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：118
• 期：3
• 页码：485-491
• 全文大小：502 K

文摘

To evaluate whether local tumor control probability (TCP) in stereotactic body radiotherapy (SBRT) varies between lung metastases of different primary cancer sites and between primary non-small cell lung cancer (NSCLC) and secondary lung tumors.

Materials and methods

sp0010">A retrospective multi-institutional (n = 22) database of 399 patients with stage I NSCLC and 397 patients with 525 lung metastases was analyzed. Irradiation doses were converted to biologically effective doses (BED). Logistic regression was used for local tumor control probability (TCP) modeling and the second-order bias corrected Akaike Information Criterion was used for model comparison.

Results

sp0015">After median follow-up of 19 months and 16 months (n.s.), local tumor control was observed in 87.7% and 86.7% of the primary and secondary lung tumors (n.s.), respectively. A strong dose–response relationship was observed in the primary NSCLC and metastatic cohort but dose–response relationships were not significantly different: the TCD90 (dose to achieve 90% TCP; BED of maximum planning target volume dose) estimates were 176 Gy (151–223) and 160 Gy (123–237) (n.s.), respectively. The dose–response relationship was not influenced by the primary cancer site within the metastatic cohort.

Conclusions

sp0020">Dose–response relationships for local tumor control in SBRT were not different between lung metastases of various primary cancer sites and between primary NSCLC and lung metastases.