A new novolimus-eluting bioresorbable scaffold for large coronary arteries: an OCT study of acute mechanical performance

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• 作者：Niklas F. Boeder^a ; Tim Koepp^a ; Oliver Dö ; rr^a ; Timm Bauer^a ; Alessio Mattesini^b ; Albrecht Els&auml ; sser^c ; Helge Mö ; llmann^d ; Florian Blachutzik^e ; Stephan Achenbach^e ; Alexander Ghanem^f ; Christian W. Hamm^a ; Holger M. Nef^a ; ^{holger.nef@me.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：AS ; Area stenosis ; BRS ; Bioresorbable scaffold ; DES ; Metallic drug-eluting stent ; ISA ; Incomplete strut apposition ; IVUS ; Intravascular ultrasound ; MACE ; Major adverse cardiac events ; MLA ; Minimal Lumen area ; MLD ; Minimum lumen diameter ; OCT ; Optical coherence tomography ; PCI ; Percutaneous coronary intervention ; QCA ; Quantitative coronary angiography ; RAS ; Residual area stenosis ; RVA ; Reference vessel area ; RVD ; Reference vessel diameter
• 刊名：International Journal of Cardiology
• 出版年：2016
• 出版时间：1 October 2016
• 年：2016
• 卷：220
• 期：Complete
• 页码：706-710
• 全文大小：908 K

文摘

To evaluate the acute performance of a novolimus-eluting bioresorbable scaffold (BRS) with a nominal diameter of 4.0 mm (DESolve® XL) using optical coherence tomography (OCT) in terms of appropriate scaffold deployment.

Methods and results

sp0050">Ten patients (55.6% male, mean age 60.0 y) undergoing OCT-guided scaffold implantation were enrolled consecutively in this retrospective study. Using data from the final pullback, the following indexes were calculated: mean and minimum area, residual area stenosis, incomplete strut apposition, tissue prolapse, eccentricity and symmetry indexes, strut fracture, and edge dissection. The clinical indication for the procedure was acute coronary syndrome in roughly half (55.5%) of the cases. All three main vessels were affected equally. The maximum post-dilatation balloon inflation pressure was 14.7 ± 4.2 atm. OCT analysis showed a lumen area of 11.4 ± 1.9 mm² and a scaffold area of 11.5 ± 2.1 mm². Mean residual area stenosis was 28.6%. No strut fractures or edge dissections were apparent. The mean eccentricity index was 0.65 ± 0.16 and the mean symmetry index 0.39 ± 0.25.

Conclusion

sp0055">The size of large vessels does not adversely influence acute mechanical performance as assessed by the eccentricity and symmetry indexes. No adverse cardiac event occurred during the hospital stay or the 30-day follow-up. It is feasible to treat large vessels with the DESolve® XL BRS.