The emerging role of mutational analysis in the management of gastrointestinal stromal tumour

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• 作者：Florian Haller
• 关键词：GIST ; KIT ; mutation analysis ; PDGFRA
• 刊名：Diagnostic Histopathology
• 出版年：2013
• 出版时间：June, 2013
• 年：2013
• 卷：19
• 期：6
• 页码：198-202
• 全文大小：146 K

文摘

Since the first description of gain-of-function mutations of the genes KIT and PDGFRA in GISTs, we have learned a lot on their diagnostic, prognostic and predictive value. This review will summarize the mutations found in GISTs in different clinical settings, and will focus on their clinical impact in daily routine diagnostics.