Vascular endothelial growth factor, p53, Rb, Bcl-2 expression and response to chemotherapy in advanced non-small cell lung cancer
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- 作者：Ludovini ; Vienna ; Gregorc ; Vanesa ; Pistola ; Lorenza ; Mihaylova ; Zhasmina ; Floriani ; Irene ; et. al.
- 关键词：Vascular endothelial growth factor ; Biological factors ; Hemoglobin level ; Cisplatin ; Lung cancer ; Response to chemotherapy
- 刊名：Lung Cancer
- 出版年：2004
- 出版时间：October, 2004
- 年：2004
- 卷：46
- 期：1
- 页码：77-85
- 全文大小：239 K
文摘
Vascular endothelial growth factor (VEGF) increases microvascular permeability and stimulates endothelial cell growth. p53 Overexpression has been associated with resistance to cisplatin-based chemotherapy in patients (pts) with NSCLC. The aim of this study was to evaluate the predictive role of VEGF for chemotherapy response, its relationship with p53, Rb, Bcl-2 and hemoglobin levels and its impact on overall survival in pts with advanced NSCLC.