Relevance of p53, bcl-2 and Rb expression on resistance to cisplatin-based chemotherapy in advanced non-small cell lung cancer

详细信息    查看全文

• 作者：Gregorc ; Vanesa ; Ludovini ; Vienna ; Pistola ; Lorenza ; Darwish ; Samir ; Floriani ; Irene ; Bellezza ; Guido ; et. al.
• 关键词：p53 ; Retinoblastoma ; bcl-2 ; Cisplatin ; Lung cancer ; Chemotherapy ; Resistance
• 刊名：Lung Cancer
• 出版年：2003
• 出版时间：January, 2003
• 年：2003
• 卷：39
• 期：1
• 页码：41-48
• 全文大小：284 K

文摘

Purpose: Tumors with p53 overexpression have been associated with enhanced resistance to cisplatin-based chemotherapy in a few and small studies involving non-small cell lung cancer. The relationships and interactions between p53, Rb and bcl-2 immunostaining, clinical parameters and response to cisplatin-based chemotherapy were evaluated in the present study. Experimental design: Histological specimens obtained by bronchial or fine-needle biopsy from patients who underwent cisplatin-based chemotherapy between 1992 and 1999 were evaluated by immunostaining. Results: There were 102 patients, 88 men. Median age was 63 years; 47 had stage III and 55 stage IV disease. Forty-six tumor samples (45 % ) had positive immunostaining for p53, 61 (59 % ) had negative immunostaining for Rb and 8 (8 % ) had positive immunostaining for bcl-2. The response rate of the group with p53 positive immunostaining was 26 % versus 57 % of the p53 negative group (P