CaL-B a highly selective biocatalyst for the kinetic resolution of furylbenzthiazole-2-yl-ethanols and acetates

详细信息    查看全文

• 作者：Lá ; szló ; Csaba Bencze ; Csaba Paizs ; Monica Ioana Toş ; a ; Maria Trif ; Florin Dan Irimie
• 刊名：Tetrahedron: Asymmetry
• 出版年：2010
• 出版时间：23 August 2010
• 年：2010
• 卷：21
• 期：16
• 页码：1999-2004
• 全文大小：431 K

文摘

A highly stereoselective enzymatic kinetic resolution of novel various substituted racemic furylbenzthiazole-2-yl-ethanols and their acetates has been developed. Both processes, the enzymatic acylation of the racemic alcohols and the enzymatic methanolysis of racemic acetates yielded highly enantiomerically enriched (ee >98 % ) resolution product, when CaL-B was used as a biocatalyst in acetonitrile. The absolute configuration of the obtained (R)-(+)-1-(5-(4-chlorobenzo[d]thiazol-2-yl)furan-2-yl)ethanol was determined by a detailed ¹H NMR study of rac- and (+)-1-(5-(4-chlorobenzo[d]thiazol-2-yl)furan-2-yl)ethanol Mosher derivatives.