Lipase-catalyzed kinetic resolution of racemic 1-(10-alkyl-10H-phenothiazin-3-yl)ethanols and their butanoates

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• 作者：Jü ; rgen Brem ; Monica-Ioana Toş ; a ; Csaba Paizs ; Anca Munceanu ; Dubravka Matković ; -Č ; alogović ; Florin-Dan Irimie
• 刊名：Tetrahedron: Asymmetry
• 出版年：2010
• 出版时间：23 August 2010
• 年：2010
• 卷：21
• 期：16
• 页码：1993-1998
• 全文大小：335 K

文摘

The synthesis of both enantiomers of 1-(10-alkyl-10H-phenothiazin-3-yl)ethanols and their butanoates by enantiomer-selective acylation of racemic alcohols with the lipase from Pseudomonas fluorescens (L-AK) or/and by methanolysis of the corresponding racemic esters with lipase B from Candida antarctica (CaL-B) is described. The absolute configuration of the enantiomerically pure enantiomers was determined by X-ray crystallography.