Enzyme-catalyzed synthesis of (R)- and (S)-3-hydroxy-3-(10-alkyl-10H-phenothiazin-3-yl)propanoic acids

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• 作者：Jü ; rgen Brem ; Monica Ioana Toş ; a ; Csaba Paizs ; Elemé ; r Vass ; Florin Dan Irimie
• 刊名：Tetrahedron: Asymmetry
• 出版年：2010
• 出版时间：1 March 2010
• 年：2010
• 卷：21
• 期：3
• 页码：365-373
• 全文大小：567 K

文摘

Starting from the racemic ethyl 3-hydroxy-3-(10-alkyl-10H-phenothiazin-3-yl)propanoates as substrates, a multienzymatic procedure was developed for the efficient synthesis of the corresponding highly enantiomerically enriched (R)- and (S)-3-heteroaryl-3-hydroxypropanoic acids.