Fiftieth anniversary of the description of the chemical structure of antibodies

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• 作者：Dolores Ramos-Bello ; Luis Llorente ; ^{fluisllorentepeters57@gmail.com}
• 关键词：Antibodies ; History ; Immunochemistry
• 刊名：Reumatolog¨ªa Cl¨ªnica (English Edition)
• 出版年：2009
• 出版时间：2009
• 年：2009
• 卷：5
• 期：6
• 页码：280-284
• 全文大小：188 K

文摘

The identification of the antitoxic property of serum in 1890 by Emil von Behring and the introduction of the term ¡°Antik?rper?by Paul Ehrlich in 1891 referring to one of the most relevant mechanisms of defense of the adaptive immune system, ie, the humoral immune response mediators, mark the beginning of modern immunology. The ¡°Y?structure was described 50 years ago by Gerald M. Edelman and Rodney R. Porter. Thus, on the fiftieth anniversary of the description of the chemical structure of antibodies, we consider it appropriate to celebrate this fact by sketching a brief outline and review of these epoch-making achievements.