Potentiation of hypericin-mediated photodynamic therapy cytotoxicity by MK-886: Focus on ABC transporters, GDF-15 and redox status
详细信息 查看全文
- 作者：Barbora Kuchá ; rová ; Jaromí ; r Mike&scaron ; Rastislav Jendželovský ; Jana Vargová ; Lucia Mike&scaron ; ová ; Zuzana Jendželovská ; Já ; n Kovaľ ; Peter Fedoročko ; peter.fedorocko@upjs.sk" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-LOX ; 5-lipoxygenase ; AA ; arachidonic acid ; ABC transporters ; ATP-binding cassette transporters ; BCRP ; breast cancer resistance protein ; BLT1 ; leukotriene B4 receptor ; CI ; combination index ; FADs ; oxidized flavins/flavin adenine dinucleotides ; FDA ; fluorescein diacetate ; GSH ; glutathione ; HBSS ; Hank's balanced salt solution ; GDF-15/NAG-1 ; growth differentiation factor 15/nonsteroidal anti-inflammatory drugs activated gene 1 ; HY ; hypericin ; HY-PDT ; hypericin-mediated photodynamic therapy ; LTB4
- 刊名：Photodiagnosis and Photodynamic Therapy
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：12
- 期：3
- 页码：490-503
- 全文大小：1865 K
文摘
- •
MK-886 pretreatment increases intracellular hypericin level in HT-29 and MCF-7 cells.
- •
MK-886 modulates ABC transporters expression and efflux activity.
- •
Along with BCRP and MRP1, MRP2 is possibly involved in hypericin efflux.
- •
GDF-15 accumulation was dispensable for MK-886 and/or HY-PDT toxicity.
- •
More toxic concentrations of both agents lead to antioxidant adaptive response.