Effect of protein corona magnetite nanoparticles derived from bread in vitro digestion on Caco-2 cells morphology and uptake
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- 作者：Desirè ; Di Silvioa ; b ; ; Neil Rigbyb ; Balazs Bajkab ; Alan Mackieb ; Francesca Baldelli Bombellic ; francesca.baldelli@polimi.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：NP ; nanoparticle ; UC ; ultracentrifugation ; PC ; protein corona ; GI ; gastrointestinal ; SSF ; simulated salivary fluid ; SGF ; simulated gastric fluid ; SIF ; simulated intestinal fluid ; PMAO ; poly (maleic)-alt-1-octadecene ; CF ; carboxyfluorescien ; FA ; fluoresceinamine ; SFM ; serum free medium
- 刊名：International Journal of Biochemistry and Cell Biology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：75
- 期：Complete
- 页码：212-222
- 全文大小：3654 K
文摘
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Digestive protein corona nanoparticles are isolated by sucrose gradient ultracentrifugation.
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Proteins enriched in the corona are partially protected during digestion.
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PC formation enhances uptake of magnetite nanoparticle in Caco-2 cells.
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Gastric and duodenal PCs induce different alterations in Caco-2 morphology.