Cognitive assessment of pycnogenol therapy following traumatic brain injury
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- 作者：Stephen W. Scheff ; sscheff@email.uky.edu" class="auth_mail" title="E-mail the corresponding author ; Kelly N. Roberts
- 关键词：ANOVA ; analysis of variance ; CCI ; controlled cortical impact ; FJB ; fluoro-jade B ; iNOS ; inducible nitric oxide synthase ; MWM ; Morris water maze ; NO ; nitric oxide ; PYC ; pycnogenol ; TBI ; traumatic brain injury
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：10 November 2016
- 年：2016
- 卷：634
- 期：Complete
- 页码：126-131
- 全文大小：1250 K
文摘
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A combinational bioflavonoid, pycnogenol, was used as a therapy enhance cognition following brain injury.
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Pycnogenol significantly reduced TBI-related cortical injury volume.
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Fluoro-jade B staining failed to demonstrate hippocampal neuroprotection.
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Pycnogenol administered post-injury did not improve Morris water maze acquisition.