A systematic review on [18F]FLT-PET uptake as a measure of treatment response in cancer patients
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- 作者：V.R. Bollinenia ; 1 ; G.M. Kramerb ; 1 ; ge.kramer@vumc.nl" class="auth_mail" title="E-mail the corresponding author ; E.P. Jansmac ; Y. Liua ; W.J.G. Oyend
- 关键词：Postitron-emission tomography ; 3&prime ; -Deoxy-3&prime ; -(18F)fluorothymidine ; Alovudine ; Cell proliferation ; Neoplasms ; Chemotherapy ; Radiotherapy ; Chemoradiotherapy ; Imaging biomarker
- 刊名：European Journal of Cancer
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：55
- 期：Complete
- 页码：81-97
- 全文大小：693 K
文摘
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We performed a systematic review on 18F-fluorothymidine ([18F]FLT) as imaging biomarker of treatment response.
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[18F]FLT positron emission tomography ([18F]FLT-PET) seems to be a good predictor of early response to chemotherapy, radiotherapy and chemoradiotherapy.
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[18F]FLT uptake shows a good correlation with progression-free survival and disease-free survival.
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Correlation between [18F]FLT uptake and overall survival is less consistent.
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Interventional studies are needed to confirm the clinical impact of [18F]FLT-PET.