The kinetics and protection of the antiviral state induced by recombinant iIFN1a in rainbow trout against infectious hematopoietic necrosis virus
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- 作者：Yongsheng Caoa ; b ; caoyongsheng@hrfri.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Liming Xua ; lmxu0917@163.com" class="auth_mail" title="E-mail the corresponding author ; Scott E. LaPatrac ; scott.lapatra@clearsprings.com" class="auth_mail" title="E-mail the corresponding author ; Jingzhuang Zhaoa ; zhaojingzhuang@hrfri.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Miao Liua ; 446048847@qq.com" class="auth_mail" title="E-mail the corresponding author ; Hongbai Liua ; liuhongbai@sina.com" class="auth_mail" title="E-mail the corresponding author ; Tongyan Lua ; lutongyan@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Qiya Zhangb ; zhangqy@ihb.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：iIFN1a of rainbow trout ; Prokaryotic expressing ; Antiviral state against IHNV in vivo ; Variant protection
- 刊名：Molecular Immunology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：76
- 期：Complete
- 页码：55-61
- 全文大小：1731 K
文摘
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The antiviral activity of iIFN1a against IHNV was 1.69 × 107 U/mg in CHSE-214 cells.
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The iIFN1a was potent to induce the antiviral state in vivo promptly.
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The iIFN1a can completely protect the fish from the IHNV challenge within 1 dpi.
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The variant protection correlated closely with the kinetic profile of antiviral state.