Breast cancer carcinoma-associated fibroblasts differ from breast fibroblasts in immunological and extracellular matrix regulating pathways
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- 作者：I. Pasanena ; b ; ilkka.pasanen@oulu.fi" class="auth_mail" title="E-mail the corresponding author ; S. Lehtonena ; b ; c ; R. Sormunend ; S. Skarpe ; f ; g ; h ; E. Lehtilahtia ; M. Pietilä ; i ; R. Blanco Sequeirosj ; P. Lehenkaria ; b ; k ; P. Kuvajaa ; l
- 关键词：α-SMA ; alpha-smooth muscle actin ; Tgfbr2 ; transforming growth factor &ndash ; beta receptor 2 ; HGF ; hepatocyte growth factor ; ER ; estrogen receptor ; Her2 ; human epidermal growth factor receptor 2 ; CAF ; carcinoma-associated fibroblast ; HIF-1α ; hypoxia inducible factor -1 alpha ; TGF-β ; transforming growth factor-beta ; MSC ; mesenchymal stromal cell ; NF ; fibroblast from normal breast area ; TEM ; transmission electron microscope ; FNX ; fibronexus ; ER ; endoplamic reticulum ; CpG ; cytosine-phosphate-guanine
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：344
- 期：1
- 页码：53-66
- 全文大小：2395 K
文摘
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CAFs differed from NFs in their gene expression in microarray analysis.
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In hypoxia, the expression of PDK1 and PDK4 was lower in CAFs when compared to NFs.
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In normoxia, CAFs’ expression of GLUT-1 and PDK1 was increased when compared to NFs.
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Cells with myofibroblast features were present in both NF and CAF samples.
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Cell surface markers of CAFs and NFs were indistinguishably similar.