Urachal Adenocarcinoma in a Dog
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- 作者：S. Shrader&lowast ; ; sms0059@auburn.edu" class="auth_mail" title="E-mail the corresponding author ; J. Lauridson&dagger ; ; Z. King&Dagger ; ; J. Loch&Dagger ;
- 关键词：dog ; urachal adenocarcinoma ; urachal remnant ; urachus
- 刊名：Journal of Comparative Pathology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：154
- 期：4
- 页码：304-308
- 全文大小：1503 K
文摘
An 8-year-old neutered female Labrador retriever was presented with a 3-year history of intermittent haematuria. Ultrasonographic evaluation of the urinary bladder revealed a 2 × 3 × 0.5 cm intraluminal mass arising at the dome. The mass was excised via partial cystectomy. Histopathological examination revealed neoplastic epithelial cells arranged in sheets, irregularly-branching tubules and acini within a fibrovascular stroma. Neoplastic cells were cuboidal to polygonal with abundant foamy amphophilic cytoplasm, typically with a single, large, clear intracytoplasmic vacuole and eccentric nucleus (‘signet ring’ cells). Neoplastic tubules were often ectatic and contained abundant mucin. Immunohistochemically, the neoplastic cells had weak, cytoplasmic immunoreactivity for cytokeratin 7 and rare, but strong, nuclear immunoreactivity for CDX2. Based on the cellular morphology, immunolabelling characteristics and anatomical location, a diagnosis of adenocarcinoma of urachal origin was made. To the authors' knowledge, this is the first reported case of urachal adenocarcinoma in a dog.