Spatial and temporal age-related spectral alterations in benign human breast tissue
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- 作者：Georgios Theophilou ; Simon W. Fogarty ; Jú ; lio Trevisan ; Rebecca J. Strong ; Kelly A. Heys ; Imran I. Patel ; Helen F. Stringfellow ; Pierre L. Martin-Hirsch ; Francis L. Martin ; f.martin@lancaster.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aetiology ; Biospectroscopy ; Breast cancer ; Multivariate analysis ; Synchrotron radiation-based Fourier-transform infrared (SR-FTIR) microspectroscopy ; Terminal ductal lobular unit
- 刊名：Journal of Molecular Structure
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：1106
- 期：Complete
- 页码：390-398
- 全文大小：2490 K
文摘
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SR-FTIR microspectroscopy to examine benign breast tissue.
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PCA-LDA of IR spectra shows inter-individual and age-related epithelial differences.
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A subset of spectrally-distinct epithelial cells point to putative stem cells.
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Spectral changes that may occur several years prior to onset of breast cancer.
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Novel approach to shed insights into aetiology of breast cancer.