Activated GL7⁺ B cells are maintained within the inflamed CNS in the absence of follicle formation during viral encephalomyelitis

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• 作者：Krista D. DiSano^a ; ^b ; Stephen A. Stohlman^a ; ¹ ; Cornelia C. Bergmann^a ; ^{bergmac@ccf.org}
• 关键词：CNS ; Neuroimmunology ; B cell ; Ectopic follicle ; T cell ; Viral encephalomyelitis
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：60
• 期：Complete
• 页码：71-83
• 全文大小：3347 K
• 卷排序：60

文摘

B cell accumulation in the CNS does not require ectopic follicle formation. CNS accumulation of more differentiated B cells reflects peripheral activation events. Differentiated B cells in the CNS display markers of sustained local activation. B cell differentiation phenotype influences anatomical localization in the CNS.