Follicular Dendritic Cell Activation by TLR Ligands Promotes Autoreactive B Cell Responses

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• 作者：Abhishek Das¹ ; Balthasar A. Heesters¹ ; Allison Bialas¹ ; Joseph O&rsquo ; Flynn¹ ; Ian R. Rifkin³ ; Jordi Ochando⁴ ; Nanette Mittereder⁵ ; Gianluca Carlesso⁵ ; Ronald Herbst⁶ ; Michael C. Carroll¹ ; ² ; ⁷ ; ^{michael.carroll@childrens.harvard.edu}
• 关键词：follicular dendritic cells ; autoimmunity ; systemic lupus erythematosus ; interferon-α ; TLR7 ; DAMP ; CD21 ; CD35 ; immune complex
• 刊名：Immunity
• 出版年：2017
• 出版时间：17 January 2017
• 年：2017
• 卷：46
• 期：1
• 页码：106-119
• 全文大小：3874 K
• 卷排序：46

文摘

Internalization of RNP complexes via CD21 triggers TLR7 and IFN-α in mouse and human FDCs GC maintenance and α anti-nuclear antibody production are dependent on TLR7 pathway in FDCs Loss of B cell tolerance in RNP-specific lupus mice is IFNAR dependent FDCs are an essential source of type I IFN in lupus mice