Circulating follistatin in relation to energy metabolism
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- 作者：Jakob Schiø ; ler Hansena ; b ; Peter Plomgaarda ; b ; plomgaard@dadlnet.dk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cancer ; Exercise ; Fasting ; Glucagon ; Hepatokines ; Inflammation ; Liver ; Insulin resistance ; Sepsis ; TGF-β
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：433
- 期：Complete
- 页码：87-93
- 全文大小：398 K
文摘
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Circulating follistatin is increased in conditions associated with insulin resistance.
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The glucagon-to-insulin ratio has been identified to regulate circulating follistatin.
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The liver is a major source of the circulating follistatin in humans.
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This implies that circulating follistatin is related to energy metabolism.
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These observations elucidate why plasma follistatin is associated with insulin resistance.