Preparation and characterization of mesoporous bioactive glass from agricultural waste rice husk for targeted anticancer drug delivery

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• 作者：Shiow-Yi Chen^a ; ^b ; Po-Fong Chou^a ; Wai-Kong Chan^a ; Hsiu-Mei Lin^a ; ^b ; ^{hmlin@mail.ntou.edu.tw}
• 关键词：Rice husk ; Mesoporous bioactive glass ; Folic acid ; FA receptor
• 刊名：Ceramics International
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：43
• 期：2
• 页码：2239-2245
• 全文大小：899 K
• 卷排序：43

文摘

Mesoporous bioactive glass (MBG) possesses excellent biocompatibility and an important material used for bone regeneration and drug delivery. The aim of this study is to synthesize MBG from low-cost agricultural waste rice husk (rMBG) using a sol-gel process. We show that rMBG has typical characteristics of the well-ordered hexagonal mesostructure of MBG and can be grafted with folic acid (FA) and then loaded with anticancer drugs for targeting cancer cells. By loading rMBG-FA with camptothecin (CPT, a water-insoluble anticancer drug) we formed rMBG-FA/CPT, which killed cancer cells by being selectively and efficiently taken in via the cells’ FA receptors (FRs). We found that rMBG-FA/CPT showed a higher cytotoxicity to FR-overexpressed HeLa cells than to FR-deficient L929 cells. Our results indicate that low-cost rMBG offers a potentially practical medical application that can replace highly valuable MBG as well as reduce environmental pollution caused by agricultural waste.