文摘
Phytochemical investigation of the seeds of Salacia longipes var. camerunensis led to the isolation of four sesquiterpenoid derivatives, salaterpene A (1) (1伪,2尾,8尾-triacetoxy-6尾,9尾-dibenzoyloxy-4尾-hydroxy-dihydro-尾-agarofuran), salaterpene B (2) (1伪,2尾,8尾-triacetoxy-9尾-benzoyloxy-6尾-cinnamoyloxy-4尾-hydroxy-dihydro-尾-agarofuran), salaterpene C (3) (1伪,2尾-diacetoxy-6尾,9尾-dibenzoyloxy-4尾-hydroxy-dihydro-尾-agarofuran) and salaterpene D (4) (2尾-acetoxy-1伪,6尾-dibenzoyloxy-4尾-hydroxy-9尾-nicotinoyloxy-dihydro-尾-agarofuran) together with two known compounds (5 and 6). The structures of the compounds were established by means of NMR spectroscopy. Compounds 1-4 and 6 were tested in vitro for their antiplasmodial activity against Plasmodium falciparum chloroquine-resistant strain W2. All the tested compounds exhibited a moderate potency with IC50 below 2.7 渭M.