Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis
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- 作者：Brice M. Mba鈥檔ing ; Bruno N. Lenta ; Diderot T. Noungou茅 ; Cyril Antheaume ; Yanick F. Fongang ; Silv猫re A. Ngouela ; Fabrice F. Boyom ; Philip J. Rosenthal ; Etienne Tsamo ; Norbert Sewald ; Hartmut Laatsch
- 关键词：Salacia longipes ; Celastraceae ; Sesquiterpenes ; Salaterpenes A&ndash ; D ; Antiplasmodial activity
- 刊名：Phytochemistry
- 出版年：December, 2013
- 年：2013
- 卷：96
- 期：Complete
- 页码：347-352
- 全文大小：436 K
文摘
Phytochemical investigation of the seeds of Salacia longipes var. camerunensis led to the isolation of four sesquiterpenoid derivatives, salaterpene A (1) (1伪,2尾,8尾-triacetoxy-6尾,9尾-dibenzoyloxy-4尾-hydroxy-dihydro-尾-agarofuran), salaterpene B (2) (1伪,2尾,8尾-triacetoxy-9尾-benzoyloxy-6尾-cinnamoyloxy-4尾-hydroxy-dihydro-尾-agarofuran), salaterpene C (3) (1伪,2尾-diacetoxy-6尾,9尾-dibenzoyloxy-4尾-hydroxy-dihydro-尾-agarofuran) and salaterpene D (4) (2尾-acetoxy-1伪,6尾-dibenzoyloxy-4尾-hydroxy-9尾-nicotinoyloxy-dihydro-尾-agarofuran) together with two known compounds (5 and 6). The structures of the compounds were established by means of NMR spectroscopy. Compounds 1-4 and 6 were tested in vitro for their antiplasmodial activity against Plasmodium falciparum chloroquine-resistant strain W2. All the tested compounds exhibited a moderate potency with IC50 below 2.7 渭M.