Central nervous system involvement in breast cancer patients: Is the therapeutic landscape changing too slowly?
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- 作者：Caterina Fontanellaa ; b ; Elisa De Carloa ; b ; Marika Cinauseroa ; b ; Giacomo Pelizzaria ; b ; Ilaria Venutia ; Fabio Puglisia ; b ; fabio.puglisi@uniud.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Metastatic breast cancer ; Central nervous system involvement ; Breast cancer subtypes ; Locoregional and systemic treatment
- 刊名：Cancer Treatment Reviews
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：46
- 期：Complete
- 页码：80-88
- 全文大小：724 K
文摘
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Incidence of CNS involvement from metastatic BC (mBC) 10–16% in literature versus 36% in autopsy studies.
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WBRT is the standard of therapy for mBC patients with multiple brain metastases.
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Patients with oligometastatic disease should be considered for radical surgery or stereotactic radiosurgery (SRS).
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The addition of lapatinib to trastuzumab increases OS in patients with CNS involvement by HER2-positive BC.
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Systemic treatment options for TNBC and luminal-like BC are still very limited.