Disruption of the Phosphate Transporter Pit1 in Hepatocytes Improves Glucose Metabolism and Insulin Signaling by Modulating the USP7/IRS1 Interaction
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- 作者：Anne Forand1 ; 2 ; 6 ; anne.forand@inovarion.com" class="auth_mail" title="E-mail the corresponding author ; Eugé ; nie Koumakis1 ; 3 ; Alice Rousseau1 ; Yohann Sassier1 ; Clé ; ment Journe4 ; Jean-Franç ; ois Merlin5 ; Christine Leroy1 ; Valé ; rie Boitez1 ; Patrice Codogno1 ; Gé ; rard Friedlander1 ; Isabelle Cohen1
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：6 September 2016
- 年：2016
- 卷：16
- 期：10
- 页码：2736-2748
- 全文大小：3009 K
文摘
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Hepatocyte-specific Pit1-KO protects against HFD-induced obesity and diabetes
Pit1 deletion delayed an insulin negative feedback loop, sustaining insulin signaling
USP7 is a PiT1 binding partner
Pit1 deletion inhibited USP7/IRS1 dissociation upon insulin stimulation